Carotid intimamedia thickness cimt and carotid lumen diameter cld are strong indicators of cardiovascular event risk and stenosis severity, respectively. Details regarding the control and nonmorquio mps cohorts have been published 11, 12. Dec 12, 20 t1 ecgbased frame selection and curvaturebased roi detection for measuring carotid intima media thickness. Dr bots reported receiving study grants for studies on carotid intima media thickness andor honoraria for professional input on carotid intima media thickness issues from astrazeneca, icelandic heart foundation, organon, pfizer, the netherlands heart foundation, the netherlands organisation for health research and development, servier, and. Cimt has been frequently utilized in clinical trials to test the efficacy of cardiovascular drugs. Carotid intima media thickness imt is a cvd risk factor, thus the aim of the study was to determine if an association between dietary p, especially food additive phosphate fap, intake, and imt exists. The purpose of this study was to investigate the interobserver variability of manual and also of computer software measurements of imt. Carotidartery intima and media thickness as a risk factor. Measurements of carotid intima media thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events. Ashokkumar l1, rajendran p2 1department of computer science and engineering, k.
Carotid intima media thickness reference intervals for a. The aim of this study was to evaluate the presence of common carotid artery cca intima media thickness imt and circulation inflammation markers in patients with dd. Intimal thickening is one of the first signs of atherosclerosis and can be measured with cimt. The test measures the thickness of the inner two layers of the carotid arterythe intima and media and alerts physicians to any.
We studied the associations between the thickness of the. Growing evidence indicates that depressive disorders dds are an important risk factor for atherosclerosis. This study aimed to compare the feasibility and reproducibility of manual imt and auto imt measurement in. The carotid intimamedia thickness test cimt is a measure used to diagnose the extent of carotid atherosclerotic vascular disease. To enhance diagnostic effectiveness, an ultrasound software tool has been developed that can measure the thickness of the intima media layers of the carotid artery, for assessing an asymptomatic patients risk of developing cardiovascular disease. The national cholesterol education program adult treatment panel iii identified imt as a method to. Predictive value for cardiovascular events of common. Carotid intimamedia thickness in diabetics and hypertensive. Carotid intima media thickness cimt was one of the first available methods to display the atherosclerotic lesion and is commonly used in clinical trials as an endpoint thoenes et al. The current study aims to check the relationship between parameters derived from brachial blood pressure, the carotid artery intima media thickness imt, pulse wave velocity pwv and. Relationship between blood glucose and carotid intima media. Carotid artery intimamedia thickness, distensibility and.
Careful evaluation of cimt studies reveals discrepancies in the comprehensiveness with which cimt is assessedthe number of carotid segments evaluated common carotid artery cca, internal carotid artery ica, or the carotid bulb, the type of measurements made. Ultrasound software tool measures carotid intimamedia thickness. Simply select your manager software from the list below and click on download. Adult carotid intimamedia thickness, dietary fats, and. A suitable marker for atherosclerosis, however, should meet several criteria before it can be validly used. Automated measurement of intimamedia thickness of carotid. Intima media thickness imt determined by bmode ultrasonography is comparable to the thickness of intima media complexes as determined by histologic examination. Intimamedia thickness segmentation using weighted graph. Carotid intimamedia thickness cimt has been shown to predict cardiovascular cv risk in multiple large studies. We aimed to investigate the change of cimt in prediabetes and type2 dm patients compared to subjects with normal glucose metabolism ngm. Us6817982b2 method, apparatus, and product for accurately. This plugin helps in extracting the intima media thickness imt of the far wall of the common carotid artery from the.
This study was conducted to examine the effects of age and gender on cimt and cutoff values for cimt in different age groups. Measurements were performed on a ge vivid 3 ultrasound scanner. Citeseerx intimamedia thickness of the common carotid. Intima media thickness imt has been proposed to be a morphological criterion of atherosclerosis. N2 carotid intima media thickness cimt measurement is a sensitive, and highly reproducible technique for cardiovascular risk stratification. Second, mean and standard deviation sd agerelated equations were. A single measurement of cimt and plaque assessment improves predictions of risk of cardiovascular disease,1,2 and accaha guidelines3 support the use of cimt and plaque measurement for cardiovascular risk stratification with a class iia recommendation ie, evidence. Objectives to describe a wellestablished marker of cardiovascular risk, carotid intimamedia thickness imt and related measures artery distensibility and elasticity in children aged 1112 years old and midlife adults, and examine associations within parentchild dyads. Cca intima media thickness imt and circulation inflammation markers in patients with dd. Background and purpose in this study, we investigated intima media thickness and plaque occurrence in the carotid arteries of men with borderline hypertension compared with that in normotensive con.
Reference intervals for common carotid intimamedia thickness. Prediction of clinical cardiovascular events with carotid. At the heart of the system is computer software developed by nasas jet propulsion laboratory. Jan 27, 2015 the commercially available semiautomatic intimamedia thickness measurement software math 3. If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. The carotid imt can be simply, noninvasively, and reproducibly measured through bmode.
Common carotid artery intima media thickness ccimt is widely used as a surrogate marker of atherosclerosis, given its predictive association with cardiovascular disease cvd. Biochemistry parameters were examined by routine methods. Intimamedia thickness of carotid artery and aortic pulse. Carotid intimamedia thickness values are significantly high. Carotid intima media thickness measurement through semiautomated detection software and analysis of vascular walls. A total of 60 hypercholesterolemic patients were enrolled. Effect of rosuvastatin on progression of carotid intimamedia. Carotid intimamedia thickness cimt to assess drug efficacy. Mannheim carotid intimamedia thickness and plaque consensus. Is intimamedia thickness a predictor for cardiovascular. Stiffness parameters, intima media thickness and early atherosclerosis in systemic lupus erythematosus patients show all authors. There are a few studies demonstrating an increase in intima media thickness imt of the common carotid artery cca after radiotherapy, especially in head and neck cancers.
Measurement of the abdominal aortic intima media thickness by external ultrasound is a noninvasive methodology for quantifying the extent and severity of early. A method for determining the intima media thickness of the near andor far wall of a blood vessel according to claim 1, including inputting into the computer a database of the intima media thickness, and possibly the presence of plaque combined with patient information consisting of some or all, but not limited to, age, gender, typical. The aim of this study was to determine cimt ris in a cohort of 1012 healthy subjects from argentina. Carotid intima media thickness cimt increases in patients with adult type2 diabetes mellitus dm and is used for early detection of macrovascular complications.
The result of this injury can be severe and lifethreatening. Carotid intima media thickness and its relations with the complications in patients with type 1 diabetes mellitus tip 1 diyabetes mellituslu hastalarda karotis intima media kal. Intima media thickness imt, flowmediated dilation fmd of the brachial artery, and nitroglycerinemediated dilation. Carotid averimt measurement using the new intimascope software may provide a more precise and. Carotid intimamedia thickness cimt is probably the most commonly used marker for atherosclerotic disease as an alternative for cardiovascular morbidity and mortality. Original article from the new england journal of medicine extendedrelease niacin or ezetimibe and carotid intimamedia thickness nejm group.
Cardiovascular risk factors and increased carotid intima. Aortic intima media thickness measured by transabdominal ultrasound aimt is an intermediate phenotype of cardiovascular risk. Recently, a newly developed software allows semiautomatic measurement of mean imt auto imt. The difference in intima media thickness between diabetics and controls and between hypertensive patients and controls, adjusted for age, was 0. Measurements of carotid intimamedia thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events. Common carotid intimamedia thickness and risk of stroke and. Analyses were performed with common carotid intima media thickness used as a continuous variable per sd and as a categorized variable based on quintile cutoff points of the. Carotid intimamedia thickness test cimt cedarssinai. Measurements of carotid intima media thickness in non. Spectral doppler and automated softwareguided ultrasound. The association between carotid intima media thickness cimt and cardiovascular disease is well established. The objective of this study was to evaluate the correlation between articular and carotid ultrasound data and laboratory and clinical variables in patients with. Original article from the new england journal of medicine extendedrelease niacin or ezetimibe and carotid intima media thickness nejm group.
Usefulness of the semiautomated edgedetection software. The automated softwareguided ultrasound assessment of. Pdf carotid intimamedia thickness measurement through. The interpretation of ccimt values has been hampered by the absence of reference values, however.
Predictive value for cardiovascular events of common carotid intima. Carotid intimamedial thickness measured on multiple ultrasound. Carotid intimamedia thickness and cardiovascular events. The measurement of intimamedia thickness imt of large superficial arteries. Evaluation of a new carotid intimamedia thickness measurement. Correlation of carotid intima media thickness with disease. Intimamedia thickness imt provides a surrogate end point of cardiovascular outcomes in. Carotid intima media thickness test a carotid intima media thickness test cimt is used to determine the extent of plaque buildup in the walls of the arteries supplying blood to the head. Evaluation of a new carotid intimamedia thickness measurement by bmode ultrasonography using an innovative measurement software, intimascope. The aim of this study was to evaluate the feasibility and accuracy of commercially available software directly implemented on the ultrasound scanner for automated measurement of the intima media thickness imt of the common carotid artery on source images. We have developed dicombased software that measures cimt.
We performed this study to evaluate the feasibility and accuracy of the newly developed korean software ks for measurement of the carotid intima media thickness imt. The carotid intima media thickness imt is a widely used surrogate marker for atherosclerosis worldwide. If a cimt shows increased thickness in the inner layers of the carotid artery, you may be at risk for cardiovascular disease. The commercially available semiautomatic intimamedia thickness measurement software math 3. Carotid ultrasonography was performed by a mylab 70 scanner esaote. Prediction of clinical cardiovascular events with carotid intima. Accordingly, several carotid intima media thickness measurements as well as plaque were related to established cardiovascular risk factors. Jun 12, 2008 the aim of this study was to evaluate the feasibility and accuracy of commercially available software directly implemented on the ultrasound scanner for automated measurement of the intima media thickness imt of the common carotid artery on source images. Intima media thickness segmentation using weighted graph based active contour technique. Intimamedia thickness an overview sciencedirect topics.
Intimamedia thickness imt determined by bmode ultrasonography is comparable to the thickness of intimamedia complexes as determined by histologic examination. Carotid intimamedia thickness cimt was one of the first available methods to display the atherosclerotic lesion and is commonly used in clinical trials as an endpoint thoenes et al. Assessment of intimamedia thickness of carotid arteries. The carotid intima media thickness was assessed in 8 subjects 64 men and 74 women aged 2079 years whose age and sex were homogeneously distributed. Article information, pdf download for intimamedia thickness. Extendedrelease niacin or ezetimibe and carotid intima. Carotid intimamedia thickness and plaque in borderline. Carotid intima media thickness imt is as an indicator of atherosclerosis, and manual measurement of imt manual imt is the most applied method to assess atherosclerosis. Intima media thickness imt is a marker of subclinical atherosclerosis asymptomatic organ damage and should be evaluated in every asymptomatic adult or hypertensive patient at moderate risk for cardiovascular disease. Stiffness parameters, intimamedia thickness and early. We invite you to download a 14day fully functional trial version of cardiovascular. The final step in the analysis is the automatic transfer of these results into a mysql database. Evaluation of carotid intimamedia thickness imt using. The upper limit of normal for the mean carotid intima media thickness ranged from 0.
Carotid intimamedia thickness and circulation markers of. Ultrasound software tool measures carotid intimamedia. The authors performed a randomized controlled trial and noted that when the dietary distribution of fats met the recommended intake, there was a reduction in aortic intima media thickness and greater aortic distensibility. Carotid intimamedia thickness imt, an indicator of atherosclerosis and coronary heart disease chd. First, inter and intraobserver correlations were assessed for the. We observed an increase in intima media thickness of 0. However, measurement of intimamedia thickness imt in the artery is. Pdf measurement of the carotid intima, media and intima. Carotid intimamedia thickness and its relations with the.
Aims carotid intima media thickness cimt predicts cardiovascular cvd events, but the predictive value of cimt change is debated. Carotid intima media thickness imt is increasingly used as a surrogate and intermediate end point of early atherosclerosis. Physical manifestations of atherosclerosis may begin in early life, particularly in the abdominal aorta. Mean common carotid intima media thickness ccimt in relation to the number of risk factors rfs ie, body mass index, systolic blood pressure, triglyceride level, and lowdensity lipoprotein cholesterol level present, by sex. Background the combined thickness of the intima and media of the carotid artery is associated with the prevalence of cardiovascular disease. Background and purpose in this study, we investigated intima media thickness and plaque occurrence in the carotid arteries of men with borderline hypertension compared with that in normotensive control subjects and investigated the relations of these variables to atherosclerotic risk factors methods using bmode ultrasonography, we compared carotid artery intima media thickness and plaque. Extendedrelease niacin or ezetimibe and carotid intimamedia. The association between common carotid intima media thickness and incident myocardial infarction and stroke was evaluated by use of a logistic regression model. However, the accuracy of imt measurement depends on technical skill and the mechanical resolution of each ultrasonographic device. Careful evaluation of cimt studies reveals discrepancies in the comprehensiveness with which cimt is assessedthe number of carotid segments evaluated common carotid artery cca, internal carotid artery ica, or the carotid bulb, the type of measurements made mean or.
Increased coronary intima media thickness cimt has been associated with adverse cardiovascular outcomes, as have increased glucose levels. The current study aims to check the relationship between parameters derived from brachial blood pressure, the carotid artery intima media thickness imt, pulse wave velocity pwv and mean. The cimt was determined as the average of three measurements in each common. Atherosclerosis is the major cause of the morbidity and mortality in type 1 diabetes mellitus dm.
The test measures the thickness of the inner two layers of the carotid arterythe intima and mediaand alerts physicians to any thickening when patients are still asymptomatic. The interactive opensource software described here, cimtool, is based on active contours for measuring these indicators in clinical practice and thus helping in preventive diagnosis. Rangasamy college of technology, tiruchengode, tamil nadu, india 2department of computer science and engineering, knowledge institute of technology, salem, tamil nadu, india abstract. However, it is important to acknowledge that a positive effect of a drug on cimt is not necessarily translated into clinical benefit e. Jcm free fulltext natural history of atherosclerosis. Carotid intimamedia thickness in subjects with no cardiovascular.
The measurement is usually made by external ultrasound and occasionally by internal, invasive ultrasound catheters. With modern ultrasound scanners, imt can be easily and quickly assessed in clinical routine as well as in clinical and epidemiological research. Comparison between carotid plaque and carotid intimamedia. The effect of radioiodine on the intima media thickness of.
Relationship between blood glucose and carotid intima. Background carotid intimamedia thickness imt is increasingly used as a. The objective of this study was to assess if there is any correlation of duration and disease activity of rheumatoid arthritis with carotid intima media thickness cimt, an efficient. Reference intervals ris of carotid intima media thickness cimt from large healthy population are still lacking in latin america.
Mar 17, 2020 morquio a carotid intima media thickness. Validation of an opensource tool for measuring carotid lumen. Genoa, italy, equipped with 712 mhz linear transducer and the automated software guided technique radiofrequencyquality intima media thickness in realtime qimt, esaote, maastricht, holland. Measurements of carotid intima media thickness in noninvasive. The commercially available semiautomatic intima media thickness measurement software math 3.
Limited information is currently available about whether carotid intima media thickness imt correlates with the degree of disease activity in spondyloarthritis. We assessed the relation between cimt change and events in individuals at high cardiovascular risk. Reproducibility of aortic intimamedia thickness in. Determination of intima media thickness of common carotid artery was performed with hewlett packard sonos 5 500, using automated computer software medicasoft. Intima media thickness imt is widely measured for the evaluation of early atherosclerosis of the carotid artery. Design crosssectional study child health checkpoint, nested within a prospective cohort study, the longitudinal.
Methods and results from 31 cohorts with two cimt scans total n 89070 on average 3. We aimed to 1 investigate the reproducibility of aimt in a populationderived cohort of infants. Measurement of the carotid intimamedia thickness enables arterial wall thickening to. Ecgbased frame selection and curvaturebased roi detection. Reproducibility of aortic intimamedia thickness in infants. Reference intervals for common carotid intimamedia. Carotid intimamedia thickness cimt measured by bmode. Rheumatoid arthritis ra patients have a higher chance of adverse cardiovascular events due to accelerated atherosclerosis. Pdf carotid intimamedia thickness for atherosclerosis. Association of dietary pattern with carotid intima media. Medline, embase, scopus, and cochrane databases were searched from inception through 2009 for original research reporting.
Currently, a new automated ultrasound software, based on radio frequency, called rfqimt technology,proved to be a useful method for assessing subclinical atherosclerosis with the measurement of the intima media thickness imt in carotid arteries. The morquio a cohort n 12 was 58% male and 42% female table 1. Intimamedia thickness of brachial artery, vascular. So, what can we takeaway from these two studies looking at intima media thickness.
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